François Jacob Conference:
Evolution, Structure and Function of
Chromosomes High Order Structure
Paris, June 4-7, 2019

Considerable progress has been made in recent years in our understanding of the structure of chromosomes inside the nucleus or the bacteria, the role of long range contacts in gene regulation, the role of sub-chromosomal domains in controlling gene activation and single cell analysis. Similarly studies on the role of condensin and cohesins explain how long range contacts are stabilized and how chromosomes pair and segregate during cell division. However there is still an enormous gap in our understanding of the evolution of chromosomes structure, the physical processes that govern chromosome topology, chromosome condensation during mitosis, homology search during DNA repair or metaphase, the role of phase separation in the nucleus etc. We also do not fully understand how specific long range contacts are formed and resolved during the cell cycle, during differentiation or mitosis.

The time is ripe for the organisation of a dedicated scientific meeting to bring scientists investigating various aspects of chromosome biology, imaging, evolution, development and diseases together with physico-chemists and physicists interested in macromolecules and their assembly. We will also bring communities who do not mix frequently, those who study bacterial chromosomes, yeast and fungi with those who study invertebrates up to human and mouse cells and organisms.





Gerd Blobel, Children's Hospital of Philadelphia, Philadelphia, United States
Giacomo Cavalli, Université de Montpellier/CNRS, Montpellier, France
Denis Duboule, University of Geneva, Geneva, Switzerland
William Earnshaw, University of Edinburgh, Scotland, United Kingdom
Peter Fraser, Florida State University, Tallahassee, United States
Yad Ghavi-Helm, IGFL, CNRS, Lyon, France
Eugene Gladyshev, Institut Pasteur, Paris, France
Thomas Gregor, Institut Pasteur, Paris, France
Mitchell Guttman, California Institute of Technology, United States
Edith Heard, EMBL, Heidelberg, Germany, Institut Curie, Paris, France
Romain Koszul, Institut Pasteur, Paris, France
Gaelle Legube, CBI Toulouse, France
Kazuhiro Maeshima, National Institute of Genetics, Shizuoka, Japan
John Marko, Northwestern University, Evanston, United States
Heather Marlow, Institut Pasteur, Paris, France
Steven McKnight, UT Southwestern Medical Center, Dallas, Tx, United States
Kim Nasmyth, University of Oxford, Oxford, United Kingdom
Marcello Nollman, CNRS, Montpellier, France
Jennifer Philips-Cremins, University of Pennsylvania, Philadelphia, United States
Ana Pombo, MDC, Berlin, Germany
Dan Rokhsar, UC Berkeley, Berkeley, United States
Jeramiah Smith, University of Kentucky, Lexington, United States
Kikue Tachibana, IMBA, Vienna, Austria
Wei Xie, School of Life Sciences, Beijing, China

20 short talks will be selected among the abstracts submitted.

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