Programme
François Jacob Conference:
Evolution, Structure and Function of
Chromosomes High Order Structure
Paris, June 4-7, 2019
 
Tuesday, June 4, 2019
Opening of the meeting, Introduction
02:30 pm-03:00 pm
Session I Genome Evolution
03:00 pm-05:40 pm
Chair: Dujon Bernard, Institut Pasteur, France
0
03:00 pm

The Evolutionary History of Metazoan Karyotypes

D. Rokhsar
UC Berkeley, Berkeley, United States 
0
03:30 pm

Evolution of Vertebrate Genome Biology: Eons and Embryogenesis

J. Smith
Univ. of Kentuky, Lexington, United States 
0
04:00 pm

Coffee Break


0
04:30 pm

Diversification of genome structure/function relationships in metazoans

H. Marlow
Dept of Developmental& stem cell biology, Institut Pasteur, Paris, France 
0
05:00 pm

Two short talks


Cocktail reception
05:45 pm-08:00 pm
Wednesday, June 5, 2019
Session II Genome organisation during development and differentiation
09:00 am-12:20 pm
Chair: Tajbakhsh Shahragim,
0
09:00 am

Chromatin architecture and the Hox clock

D. Duboule
University of Geneva, Geneva, Suisse 
0
09:30 am

Dynamic folding of the X chromosome and its relationship with gene silencing during X inactivation

E. Heard
Mammalian Developmental Epigenetics Group, Institut Curie, Paris, France 
0
10:00 am

Two short talks


0
10:40 am

Coffee Break


0
11:10 am

Spatial chromatin reorganization during zygotic reprogramming to totipotency

K. Tachibana-Konwalski
IMB, Vienna, Autriche 
0
11:40 am

Two short talks


Lunch
12:20 pm-02:00 pm
Session II Genome organisation during development and differentiation (continued)
02:00 pm-04:30 pm
Chair: Fabre Emanuelle,
0
02:00 pm

Reprogramming of chromatin architecture in mammalian early development

W. Xie
School of Life Sciences, Tsinghua Univ, Beijing, China 
0
02:30 pm

In situ genome architecture of neuronal subtypes

A. Pombo
MDC, Berlin, Germany 
0
03:00 pm

Three short talks


0
04:00 pm

Chromatin and Chromosome dynamics during DNA Double Strand break repair

G. Legube
Centre de Biologie Intégrative, CBI, LBCMCP; CNRS, Toulouse, France 
Poster session with cheese and wine
04:00 pm-08:00 pm
Thursday, June 6, 2019
Session III Genome expression
09:00 am-12:20 pm
Chair: Navarro Gil Pablo, Institut Pasteur, France
0
09:00 am

Polycomb proteins and 3D genome folding in epigenetic inheritance and cancer

G. Cavalli
Institute of Human Genetics, CNRS, Montpellier, France University of Montpellier, Montpellier, France 
0
09:30 am

Enhancer-promoter interactions during Drosophila embryogenesis

Y. Ghavi-Helm
ENS, Lyon, France 
0
10:00 am

Coffee break


0
10:30 am

Three short talks


0
11:30 am

Chromosome dynamics control early developmental decisions

P. Fraser
The Barbraham Institute, Cambridge, Royaume-Uni 
0
12:00 pm

Short talk


Lunch
12:20 pm-02:00 pm
Session IV Cell Cycle and division
02:00 pm-06:00 pm
Chair: Boccard Frederick,
0
02:00 pm

Chromosomes, cohesin, and cohesion

K. Nasmyth
University of Oxford, Oxford, Royaume-Uni 
0
02:30 pm

Mapping the pathway of mitotic chromosome formation

K. Samejima1, I. Samejima1, J. Gibcus2, A. Golobdorodko2, L. Mirny2, J. Dekker3, W. Earnshaw*1
1University of Edinburgh, Edinburgh, United Kingdom 2Massachusetts Institute of Technology, Cambridge, MA, United States 3University of Massachusetts Medical School, Worcester, United States 
0
03:00 pm

Two short talks


0
03:40 pm

Coffee break


0
04:10 pm

Towards the recombination-independent mechanism of homologous DNA-DNA pairing

E. Gladyshev
Institut Pasteur, Paris, France 
0
04:40 pm

Regulation of budding yeast chromosome folding during mitosis

R. Koszul
Dept. of Genomes & Genetics, Institut Pasteur, Paris, France 
0
05:10 pm

Short talk


Visit of the Orsay museum
06:30 pm-08:00 pm
Banquet dinner - Orsay Museum
08:00 pm-23:00
Friday, June 7, 2019
Session V Genomes and disease
09:00 am-12:40 pm
Chair: Muchardt Christian,
0
09:00 am

Re-configuration of chromatin structure during the progression from mitosis into G1 phase

G. Blobel
UPenn, Philadelphia, United States 
0
09:30 am

Function and regulation of the 3D folding of the genome

F. Spitz
Developmental & Stem Cell Biology Dept., Institut Pasteur, Paris, France 
0
10:00 am

Coffee break


0
10:30 am

Three short talks


0
11:30 am

3D Epigenome reconfiguration in brain development and disease

J. Philips-Cremins
Department of Bioengineering, University of Pennsylvania, Philadelphia, United States Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States New York Stem Cell Foundation, Robertson Investigator, New York, United States 
0
12:00 pm

Two short talks


Lunch
12:40 pm-02:10 pm
Session VI Imaging and physical basis of chromosome structure and function
02:10 pm-05:40 pm
Chair: Zimmer Christophe, Institut Pasteur,
0
02:10 pm

Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus

M. Gutman
California Institute of Technology, United States 
0
02:40 pm

Chromosome organization revealed by single nucleosome imaging

K. Maeshima
Nat. Inst. of Genetic, Japan 
0
03:10 pm

A solid state conceptualization of information transfer from gene to message to protein

S. Mcknight
Department of Biochemistry, UT Southwestern Medical Center, Dallas, United States 
0
03:40 pm

Revealing eukaryotic chromosome organization and function using advanced microscopies

M. Nollman
CBS, Montpellier, France 
0
04:10 pm

Coffee Break


0
04:40 pm

Epigenetics, morphology, mechanics and function of the mammalian cell nucleus

J.F. Marko
Department of Molecular Biosciences, Department of Physics and Astronomy, Northwestern University, Evanston, United States 
0
05:10 pm

Imaging enhancer dynamics in living fly embryos

T. Gregor
Institut Pasteur, Paris, France 
Summary and Conclusions
05:40 pm-06:00 pm
0
05:40 pm

Summary and Conclusions

K. Nasmyth
University of Oxford, Oxford, United Kingdom 

 

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