François Jacob Conference:
Evolution, Structure and Function of
Chromosomes High Order Structure
Paris, June 4-7, 2019
Tuesday, June 4, 2019
Registration Desk opening
02:00 pm-02:45 pm
Opening of the meeting by Moshe Yaniv
02:45 pm-03:00 pm
Session I Genome Evolution
03:00 pm-06:00 pm
Chair: Dujon Bernard, Institut Pasteur, France
03:00 pm

The Evolutionary History of Metazoan Karyotypes

Dan Rokhsar
UC Berkeley, Berkeley, United States
03:30 pm

Evolution of Vertebrate Genome Biology: Eons and Embryogenesis

Jeramiah Smith
University of Kentucky, Lexington, United States
04:00 pm

Evolution of Chromatin Structure and Context-Specific Gene Regulation in Animals

Heather Marlow
Institut Pasteur, Paris, France
04:30 pm

Coffee Break

05:00 pm

Hominoid-specific regulatory sequences and their controllers shape human genome regulation

Julien Pontis
EPFL, Lausanne, Switzerland
05:20 pm

Impact of holocentromeres on 3D genome organization

Héloïse Muller
Institut Curie, Paris, France
05:40 pm

Insight into the architecture of the meiotic DNA double strand break complex

Bernard De Massy
CNRS, Montpellier, France
Cocktail reception
06:00 pm-08:00 pm
Wednesday, June 5, 2019
Session II Genome organisation during development and differentiation
09:00 am-12:20 pm
Chair: Tajbakhsh Shahragim,
09:00 am

The Logic of Hox Genes Regulation at Long Distances

Denis Duboule
University of Geneva, Geneva, Switzerland
09:30 am

Dynamic folding of the X chromosome and its relationship with gene silencing during X inactivation

Edith Heard
EMBL, Heidelberg, Germany, Institut Curie, Paris, France
10:00 am

Rapid reorganization of the 3D genome reveals principal features of chromosome architecture

Marijne Schijns
NKI, Amsterdam, The Netherlands
10:20 am

The non-canonical SMC protein SmcHD1 antagonises TADs and compartments on the inactive X chromosome and modulates higher-order structure of autosomes

Michal Gdula
Oxford University, Oxford, United Kingdom
10:40 am

Coffee Break

11:10 am

Higher-order chromatin structure and chromosome segregation in ageing oocytes

Kikue Tachibana
IMBA, Vienna, Austria
11:40 am

Activity and interplay of multiple condensins for the chromosome management of Pseudomonas aeruginosa

Frédéric Boccard
CNRS, Gif-Sur-Yvette, France
12:00 pm

The Escherichia coli SMC complex, MukBEF, organises the chromosome lengthwise by forming a ring-shaped axial filament

David Sherratt
University of Oxford, Oxford, United Kingdom
12:20 pm-02:00 pm
Session II Genome organisation during development and differentiation (continued)
02:00 pm-04:50 pm
Chair: Fabre Emmanuelle,
02:00 pm

Dynamic chromatin architecture in early mammalian development

Wei Xie
School of Life Sciences, Beijing, China
02:30 pm

In situ genome architecture of neuronal subtypes

Ana Pombo
MDC, Berlin, Germany
03:00 pm

Heterochromatin Protein 1α interacts with parallel RNA and DNA G-quadruplexes

Tracy Hale
Massey University, Palmerston North, New Zealand
03:20 pm

Chromatin 3D organization revealed by chromatin networks: gene-regulation, replication, and beyond

Vera Pancaldi
Centre de recherches en cancerologie de Toulouse, Toulouse, France
03:40 pm

CTCF binding controls the expression of imprinted Dlk1-Dio3 and Igf2-H19 loci by structuring allele-specific sub-domains

Benoit Moindrot
Institute for Integrative Biology of the Cell, Gif-Sur-Yvette, France
04:00 pm

Chromatin and Chromosome dynamics during DNA Double Strand break repair

Gaelle Legube
CBI Toulouse, , France
04:30 pm

Heterochromatin maintenance following DNA damage

Sophie Polo
Paris Diderot University/CNRS, Paris, France
Poster session with wine and cheese
05:00 pm-08:00 pm
Thursday, June 6, 2019
Session III Genome expression
09:00 am-12:30 pm
Chair: Navarro Gil Pablo, Institut Pasteur, France
09:00 am

3D genome folding and Polycomb proteins in development and epigenetic inheritance

Giacomo Cavalli
Université de Montpellier/CNRS, Montpellier, France
09:30 am

Enhancer-promoter interactions during Drosophila embryogenesis

Yad Ghavi-Helm
IGFL, CNRS, Lyon, France
10:00 am

Coffee break

10:30 am

The Mediator subunit MED12 restricts heterochromatin domain formation

Robin H. Van Der Weide
The Netherlands Cancer Institute, Amsterdam, The Netherlands
10:50 am

A solid state conceptualization of information transfer from gene to message to protein

Steven McKnight
UT Southwestern Medical Center, Dallas, Tx, United States
11:20 am

Nucleosomes dramatically alter nuclear exploration and target search

David McSwiggen
University of California Berkeley, Berkeley, United States
11:40 am

Chromosome Dynamics in Pre-implantation Embryo Development

Peter Fraser
Florida State University, Tallahassee, United States
12:10 pm

In silico Modelling of Chromatin Organization and Virulence Gene Activation in Plasmodium falciparum

Jyotsana Jewel Parmar
Institut Pasteur, Paris, France
12:30 pm-02:00 pm
Session IV Cell Cycle and division
02:00 pm-05:50 pm
Chair: Boccard Frederick,
02:00 pm

How does cohesin associate with chromosomal DNAs: a Hawk’s eye view

Kim Nasmyth
University of Oxford, Oxford, United Kingdom
02:30 pm

Mapping the pathway of mitotic chromosome formation

William Earnshaw
University of Edinburgh, Scotland, United Kingdom
03:00 pm

Structural and Functional Insights into Human Condensin I and II

Erin Cutts
Institute of Cancer Research, Chelsea, London, United Kingdom
03:20 pm

Cell cycle dynamics of CTCF binding and its relation to chromosome organization

Marlies Oomen
UMass Medical School, Worcester, United States
03:40 pm

Keeping nucleosomes in order during replication and mitosis

Pablo Navarro Gil
Institut Pasteur, ,
04:00 pm

Coffee break

04:30 pm

Recombination-independent recognition of DNA homology for meiotic silencing in Neurospora crassa

Eugene Gladyshev
Institut Pasteur, Paris, France
05:00 pm

Regulation of budding yeast chromosome folding during mitosis

Romain Koszul
Institut Pasteur, Paris, France
05:30 pm

3D chromatin interactions dynamics during DNA replication

Claire Marchal
Florida State University, Tallahassee, United States
Visit of the Musée d'Orsay
06:30 pm-08:00 pm
Conference Dinner - Musée d'Orsay
08:00 pm-23:00
Friday, June 7, 2019
Session V Genomes and disease
09:00 am-12:20 pm
Chair: Muchardt Christian,
09:00 am

Re-configuration of chromatin structure during the progression from mitosis into G1 phase

Gerd Blobel
Children's Hospital of Philadelphia, Philadelphia, United States
09:30 am

Intra-TAD organization and control of gene expression by distant enhancers

François Spitz
Institut Pasteur, Paris, France
10:00 am

Coffee break

10:30 am

Erosion of heterochromatin structure: a driver for cellular dysfunction during aging?

Daan Noordermeer
Institute for Integrative Biology of the Cell, Gif-Sur-Yvette, France
10:50 am

A/B differential regions in monozygotic twins discordant for trisomy 21

Stylianos Antonarakis
11:10 am

Hi-C supports the detection and interpretation of genomic rearrangements in developmental disease

Robert Schöpflin
11:30 am

3D Epigenome reconfiguration in brain development and disease

Jennifer Philips-Cremins
University of Pennsylvania, Philadelphia, United States
12:00 pm

Three-Dimensional Structure of Human Genome at the population scale

Dariusz Plewczynski
University of Warsaw, Warsaw, Poland
12:40 pm-02:10 pm
Session VI Imaging and physical basis of chromosome structure and function
02:10 pm-05:40 pm
Chair: Zimmer Christophe, Institut Pasteur,
02:10 pm

Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus

Mitchell Guttman
California Institute of Technology, , United States
02:40 pm

Chromosome organization in living human cells revealed by single nucleosome imaging

Kazuhiro Maeshima
National Institute of Genetics, Shizuoka, Japan
03:10 pm

Thin layers of planar chromatin explain the 3D organization of genomic DNA in mitotic chromosomes and interphase nuclei

Joan-Ramon Daban
Universitat Autònoma de Barcelona, Bellaterra, Spain
03:30 pm

Visualizing nanoscale chromatin structure in living cells and multicellular organism by quantitative FLIM-FRET Microscopy

David Lleres
CNRS UMR5535, Montpellier, France
03:50 pm

Revealing eukaryotic chromosome organization and function using advanced microscopies

Marcello Nollman
CNRS, Montpellier, France
04:20 pm

Coffee Break

04:40 pm

Epigenetics, morphology, mechanics and function of the mammalian cell nucleus

John Marko
Northwestern University, Evanston, United States
05:10 pm

Visualizing long-distance transcriptional activation in living fly embryos

Thomas Gregor
Institut Pasteur, Paris, France
Summary and Conclusions
05:40 pm-06:00 pm
05:40 pm

Summary and Conclusions

Kim Nasmyth
University of Oxford, Oxford, United Kingdom


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